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Allergies got you down? Ditch the dust and other yucky stuff with a hypoallergenic mattress cover. After lots of research, we found the seven best covers of 2020 for all budgets and styles.

Hypoallergenic covers come in a wide range of materials — we’re talking everything from plastic and vinyl to cotton and bamboo.

Some of our picks are simple fabric options designed to block out dust mites and allergens. Others are full-blown mattress protectors with waterproof linings. Both are good options — it just depends on what’s best for you and your bed.

We also picked covers that are comfy, easy to care for, and quiet (plastic can be a little crunchy).

Tightly woven, high quality fabric means most hypoallergenic mattress covers don’t come cheap. If the price seems high, try to think of it as an investment in your health. Better breathing and sleep are worth it, folks.

  • $ = under $26
  • $$ = $26–$40
  • $$$ = $41–$85
  • $$$$ = $86–$120

FYI: All prices are for queen-size covers.

Best overall

Protect-A-Bed AllerZip Smooth Mattress Encasement

Price: $$$$

Lots of people consider this polyester cover the gold standard of allergy mattress covers. The patented BugLock secure seal uses three zippers to block out dust mites and bedbugs, and the polyurethane backing makes it waterproof.

Bonus: It has sleep street cred. It’s been certified Asthma & Allergy Friendly by the Asthma & Allergy Foundation of America.

Cons: The polyester fabric might get too toasty.

Buy the Protect-A-Bed AllerZip Smooth Mattress Encasement online.

Best doctor-recommended

National Allergy 100-Percent Cotton Bed Bug, Dust Mite & Allergy Control Mattress Protector

Price: $$$$

The National Allergy brand has been backed by allergy and asthma specialists for more than 30 years, so you know this cover is legit. The tight cotton weave is great at protecting your mattress from dust mites and bedbugs. It comes in 12- and 16-inch pocket depths.

Cons: It’s not waterproof.

Buy the National Allergy 100-Percent Cotton Bed Bug, Dust Mite & Allergy Control Mattress Protector online.

Best budget pick

Utopia Bedding Zippered Mattress Encasement

Price: $

Here’s a no-frills pick with a polyester waterproof backing. That’s good news if you’re prone to spillage (no judgment). We also love the 360-degree zippers that keep mites and bugs at bay. Mr. Sandman stans.

Cons: The waterproof backing can feel and sound a little crinkly.

Buy the Utopia Bedding Zippered Mattress Encasement online.

Best organic option

Avocado Organic Waterproof Mattress Protector

Price: $$$$

This cover protects against dust mites, bugs, and spills while minimizing your exposure to plastic chemicals. It has a 95 percent cotton cover and an ultra-thin polyurethane layer in the middle.

Cons: The manufacturer says up front that the cover doesn’t create a fully encased seal around your mattress. So skip this one if you have serious allergies or asthma.

Buy the Avocado Organic Waterproof Mattress Protector online.

Best with deep pockets

Claritin Ultimate Allergen Barrier Mattress Protector

Price: $$$

Forming a fully encased seal around your mattress, Claritin’s polyester cover offers the protection you’d expect from a brand that specializes in allergies. But what’s really good is that this cover fits mattresses up to 18 inches deep, something you won’t get from most competitors.

Cons: It’s not waterproof.

Buy the Claritin Ultimate Allergen Barrier Mattress Protector online.

Best cooling

PlushDeluxe Premium Bamboo Mattress Protector

Price: $$

If the idea of sleeping on heat-trapping polyester makes you break a sweat, try this cover. The ultra-breathable bamboo fabric will help you sleep cooler. But don’t worry, it still blocks out irritating dust mites and bedbugs. And hey, it’s waterproof too!

Cons: The cover doesn’t have a zippered seal, so it won’t encase your mattress 💯.

Buy the PlushDeluxe Premium Bamboo Mattress Protector online.

Best pillow cover

Eco Living Friendly Evolon Allergy Pillow Protector

Price: $

These tightly woven microfiber cases have a soft, cottony texture that feels smooth and won’t crinkle. And because there’s a zipper, you know it’s keeping all the gross stuff out. Also nice: The pillowcases come in a two-pack.

Cons: These cases are European — make sure you pick the right size for your pillows before ordering.

Buy the Eco Living Friendly Evolon Allergy Pillow Protector online.