Ever wonder why a shot of tequila hurts (so good)? This video from SciShow explains that the three-alarm blaze in your throat is actually just ethanol messing with a heat receptor called VR1. Normally, the receptor alerts our brain that something hot, like soup, is coming in. But good old ethanol throws everything out of whack, lowering the temperature where things start feeling hot, so your 98.6-degree body temp is enough to kick-start that "oh my god, what's burning" sensation.
Here's Why Alcohol Burns Going Down